The signs and symptoms of amyotrophic lateral sclerosis differ based on which neurons get damaged first.
ALS causes muscles to become smaller (atrophic), weaker and softer; or stiffer, tighter, and spastic. Therefore, at the start, symptoms begin with muscle twitches.
ALS symptoms may be restricted to a particular body location, or they may impact various parts of the body.
When ALS starts with progressive bulbar palsy in motor neurons of the brainstem, the muscles responsible for swallowing and speaking are the first to be damaged. The onset of respiratory symptoms that start in the respiratory muscles is rare.
Here are the common symptoms and signs that occur in the majority of people who have amyotrophic lateral sclerosis:
· Difficulty walking or performing routine daily activities
· Falling and tripping
· Weakness in your legs, feet or ankles
· Hand clumsiness or weakness
· Slurred speech or swallowing difficulties
· Cramping muscles and twitching in your arms, shoulders, and tongue
· Crying, laughing or yawning when inappropriate
· Changes in cognition and behaviour
Amyotrophic lateral sclerosis symptoms begin in the hands, feet, or limbs and extend to other body regions. The muscles weaken as the disease progresses, and nerve cells get destroyed. Chewing, swallowing, speaking, and breathing are all affected.
As the disease advances, symptoms spread and specific muscles become paralyzed, while others are weaker or unaffected. The majority of voluntary muscles in late-stage ALS are paralyzed.